Product Information
Simparica Trio for Large Dogs is a once-monthly liver-flavoured chew from Zoetis that protects dogs 20.1 to 40 kg against fleas, paralysis ticks, brown dog ticks, bush ticks, mange and ear mites, heartworm, and intestinal worms in a single product. The green-pack variant is dosed for the 20.1 to 40 kg weight band, with three actives — sarolaner, moxidectin, and pyrantel — covering external and internal parasites that most Australian dogs encounter.
Health Benefits
- 100% effective heartworm prevention: moxidectin prevents heartworm disease when given monthly, eliminating the need for separate heartworm tablets or annual injections
- Fast-acting flea kill, starts in 4 hours: sarolaner begins killing fleas within 4 hours of dosing and continues for 35 days, breaking the flea life cycle before eggs are laid and reducing the risk of flea allergy dermatitis
- Paralysis tick kill within 24 hours: 98.9% of pre-existing paralysis ticks killed within 24 hours of administration (Zoetis Simparica Trio product information), with 35 days of ongoing protection against re-infestation — critical for dogs in tick-prone regions of eastern Australia
- Intestinal worm coverage: pyrantel treats adult and immature roundworm and hookworm in dogs, reducing egg shedding and helping protect your household from worm transmission to humans
- Mange and ear mite control: treats and controls demodectic mange, sarcoptic mange, and ear mites, often eliminating the need for separate mite-specific treatments
- Taste-guaranteed liver chew: most dogs accept the chew from the hand without resistance; Zoetis backs this with a taste guarantee
Simparica Trio is one of the broadest-spectrum monthly flea, tick, and worming treatments for dogs in Australia, designed to replace multiple separate products with a single monthly chew for large dogs.
What It's Used For
- Flea infestation and prevention: kills adult fleas within 4 hours and breaks the flea life cycle by killing fleas before they reproduce — useful for dogs with flea allergy dermatitis or in flea-heavy environments
- Paralysis tick prevention: protects against the Australian paralysis tick, the leading tick-related cause of severe illness and death in dogs along eastern Australia
- Other tick species: treats and controls brown dog ticks and bush ticks
- Heartworm prevention: a monthly alternative to separate heartworm tablets or annual heartworm injections
- Intestinal worms: covers adult and immature roundworm and hookworm, the two intestinal worms most commonly shed by Australian dogs
- Sarcoptic and demodectic mange: treats and controls both forms of mange mites that drive severe itch, hair loss, and skin damage
- Ear mites: treats and controls ear mites, reducing reliance on separate ear-mite drops
Ingredients & Composition
Each Simparica Trio chew for large dogs (20.1 to 40 kg, green pack) contains three actives: Sarolaner (kills fleas, ticks, and mites), Moxidectin (prevents heartworm), and Pyrantel (treats roundworm and hookworm). Per-chew amounts scale with the weight band — confirm dosage on the physical pack. Liver-flavoured chew base with standard tablet binders.
Product Specifications & Care
- Species: Dog
- Life stage: Puppies from 8 weeks of age and 1.25 kg minimum body weight, adults, and seniors
- Weight range: 20.1 to 40 kg (green pack)
- Best for: Large breed dogs needing all-in-one monthly flea, tick, mite, heartworm, and intestinal worm protection in a single chew
- Not suitable for: Dogs outside the 20.1 to 40 kg band (use the size-matched variant); dogs hypersensitive to any of the three actives
- Tapeworm: Simparica Trio does not cover tapeworm — dogs at hydatid or tapeworm risk need a separate tapewormer such as praziquantel-containing products
- Collie-type breeds: safety data shows Simparica Trio is well tolerated in Border Collies, Australian Shepherds, and other Collie-related breeds at the labelled dose
- Storage: Below 30 °C (room temperature). Keep chew in blister pack until use
- Prescription required: No — available over-the-counter in Australia (vet consultation recommended for size-band confirmation)
How to Give Simparica Trio for Large Dogs
Give one chew orally with or without food, once every month. The liver-flavoured chew can be given from the hand or hidden in a small treat. For continuous protection, dose on the same calendar day each month.
| Body weight | Dose (green pack) | Frequency |
|---|---|---|
| 20.1 to 40 kg | 1 chew | Once monthly |
For year-round paralysis tick and heartworm protection along eastern Australia, dosing should be continuous and not seasonal. Mark the same day each month as the dosing day; missed doses interrupt the protective window.
Why Dr Jack Ayerbe Recommends It
“Simparica Trio is one of the broader-spectrum monthly chewables on the Australian market — three actives across fleas, paralysis tick, mites, heartworm, and intestinal worms in one product. For families with large dogs that live outdoors or travel into tick-prone areas, a fast-acting monthly chew is the difference between consistent protection and missed doses. The two things I emphasise to owners: it doesn't cover tapeworm, so if your dog has any access to raw offal or lives in a hydatid area you need a separate tapewormer on a 6-weekly cycle; and if your dog presents with sudden weakness, breathing difficulty, or wobbliness, treat it as a possible paralysis tick emergency regardless of preventative status and contact your vet immediately.”
— Dr. Jack Ayerbe OAM, Veterinarian & Vets Love Pets Partner
Shipping
Non-Prescription Products:
• Free shipping on metro orders over $49+.
• Shipping fee for regional orders & metro orders under $49 will be calculated at checkout.
Prescription Medications:
Shipped separately via express shipping at a flat rate of $9.49, or select free standard shipping*.
Returns
Non-Prescription Products:
We offer a hassle-free return policy within 30 days for unopened items in original condition for exchange or store credit. Refunds are available if the product is faulty or not as described; however, food or treats cannot be returned once opened.
Prescription Medications:
We cannot accept change of mind returns for prescription products, given that there are laws that prohibit the resale of medication. Please make your selections carefully, and double-check your order before submitting.
Palatability Guarantee
Our Palatability Guarantee applies to selected brands, including Advance, Royal Canin, Purina, Hill's and 4CYTE, allowing you to return any unused portion of dry/wet food for an exchange or full refund.
Frequently Asked Questions
The green-pack Simparica Trio is dosed for large dogs from 20.1 to 40 kg. Other size bands exist for puppies and smaller adult dogs. Always weigh your dog before ordering — using a size band below your dog's actual weight reduces effectiveness, and the band above wastes active ingredient.
Simparica Trio does not cover tapeworm — it covers roundworm and hookworm only. Dogs at risk of tapeworm (those that hunt, scavenge, eat raw meat, live in hydatid tapeworm areas, or have flea infestations carrying flea tapeworm) need a separate tapewormer such as praziquantel-containing tablets every 6 weeks or as your vet directs. For comparison with other parasite product combinations, see Dr Jack's guide to the best dog parasite treatments and preventatives.
Simparica Trio does not require a vet prescription — it's available over the counter in Australia. We do recommend speaking with your vet to confirm the right size band based on your dog's current weight as part of a broader preventative care plan.
Simparica Trio is safe for Border Collies, Australian Shepherds, and other Collie-type breeds at the labelled dose. Regulatory safety data shows it's well tolerated in these breeds because the moxidectin is used at a lower dose than older parasiticides and has been specifically evaluated in Collie-type breeds. As with any monthly preventative, follow the labelled dose for your dog's current weight band — don't double-dose if you miss a month.
Simparica Trio and NexGard Spectra are both monthly chewable all-in-one parasite products, with different active ingredients. Simparica Trio uses sarolaner + moxidectin + pyrantel; NexGard Spectra uses afoxolaner + milbemycin oxime. Simparica Trio kicks in slightly faster on fleas (4 hours vs 8 hours); NexGard Spectra covers whipworm in addition to roundworm and hookworm. Neither covers tapeworm. Your vet can advise on the right pick for your dog's specific lifestyle and parasite risk. See Dr Jack's parasite treatment guide for a full comparison.
