Clomipramine for Dogs: Medication & Safety Guide

Schedule 4 (Prescription Only): Clomipramine is a prescription medication registered by the APVMA for use in dogs in Australia.

It is commonly found under brand names such as Clomicalm or Clomav. It is specifically indicated as an aid in the treatment of separation-related disorders in dogs, when used in conjunction with behavioural modification techniques. This medication must only be used under the direct supervision and prescription of a registered veterinarian.

For detailed technical data, you can view the official Product Information (PI) via the APVMA PubCRIS database.

Clomipramine is a medication used by veterinarians to assist dogs suffering from separation anxiety. It is prescribed to help reduce the distress associated with being left alone, which often manifests as destructive behaviour, excessive barking, or inappropriate elimination. It is intended to be used as part of a total treatment strategy that includes environmental management and behavioural training.

Clomipramine belongs to a class of drugs known as Tricyclic Antidepressants (TCAs). It works by increasing the levels of certain chemical messengers (neurotransmitters) in the brain, specifically serotonin and noradrenaline. By modulating these chemicals, the medication helps to lower the dog's baseline level of anxiety, making them more receptive to learning new, calmer behaviours.

Tablets: Available in various strengths (e.g., 5 mg, 20 mg, and 80 mg) to allow for precise dosing based on the dog's body weight, like Clomav Tablets or Clomicalm Tablets for Dogs.

Dosing Note: Your veterinarian will calculate the specific dose for your dog. It is typically administered twice daily. While it can be given with or without food, giving it with a small amount of food may help improve absorption and reduce potential stomach upset.

Safety Parity Notice: While generally well-tolerated when used as directed, it is important to monitor your dog for the following potential reactions:

• Digestive Issues: Mild vomiting, diarrhoea, or a temporary change in appetite.
• Lethargy: Your dog may appear more tired or sedated, particularly when first starting the medication.
• Urinary Changes: On rare occasions, it may cause difficulty in urination (urinary retention).

This medication should not be used in the following circumstances:

• Male Breeding Dogs: Not recommended for use in male dogs intended for breeding, as it may affect testicular function.
• MAOI Use: Must not be used in conjunction with, or within 14 days of, Monoamine Oxidase Inhibitors MAOIs.
• Known Allergy: Do not use if your dog has a known hypersensitivity to clomipramine or other tricyclic antidepressants.

The following conditions require careful consideration and monitoring by your vet:

• Heart Disease: Use with caution in dogs with pre-existing heart conditions or arrhythmias.
• Glaucoma: Caution is advised in dogs with a history of glaucoma or increased intraocular pressure.
• Liver & Kidney Function: Dose adjustments may be necessary for pets with impaired liver or kidney function.
• Seizure History: Use with caution in dogs with a history of epilepsy or seizures, as the medication may lower the seizure threshold.

Temperature: Store at room temperature (below 25°C) in a dry area.

Security: Keep the medication in its original child-resistant container and store itstrictly out of reach of children and other animals.

How long does it take to see results?
While some effects may be noticed early on, it typically takes 4 to 8 weeks of consistent daily use to reach its full therapeutic effect and see a significant change in separation-related behaviours.

Is this a sedative that will "knock out" my dog?
No. While mild drowsiness can be a side effect initially, the goal is not to sedate the dog but to reduce their anxiety so they can learn to cope with being alone.

Can I stop the medication as soon as my dog is better?
No. Stopping Clomipramine abruptly can lead to a return of symptoms. Your veterinarian will provide a tapering schedule to slowly reduce the dose when they feel your dog is ready to transition off the medication.

Can I use this for occasional "scary" events like thunderstorms?
Clomipramine is designed for long-term, daily management of chronic anxiety. It is generally not effective as a "one-off" medication for situational fears like fireworks or thunder.

If your veterinarian has determined that Clomipramine is appropriate for your pet and has issued a valid Australian prescription, you can fulfil it through our pharmacy service.

Learn more about VLP Pharmacy and the prescription ordering process for medications like Clomipramine.

Disclaimer: This information is for educational purposes only and does not replace professional veterinary advice. Always consult your veterinarian before starting any new medication for your pet.