How to Use Pro-Kolin Advanced & Synbiotic D-C Together

Q: Do Pro-Kolin Advanced and Synbiotic D-C contain the same probiotic?

Yes. Both contain Enterococcus faecium, so giving both at the same time mostly overlaps rather than adds extra probiotic benefit, in dogs or cats. The main difference is Pro-Kolin Advanced's added binders and soothers (kaolin, montmorillonite, pectin, psyllium) for acute upsets, versus Synbiotic D-C's design for simple daily maintenance.

Written by: Jane Miller

Published on August 4, 2026

Last updated on August 11, 2026

Dr Jane Miller

Veterinarian & Vets Love Pets Partner

BVSc

Pro-Kolin Advanced is a probiotic paste for a short, acute digestive upset, available as a dog-specific and a cat-specific formula. Synbiotic D-C is a single daily capsule for ongoing gut health in both dogs and cats. Because they share the same core probiotic strain, you can use the paste to settle a short-term stomach upset, and the capsule as everyday maintenance.

Here's how each one works, and how to use them together so your pet gets the benefit of both without any unnecessary overlap.

Pro-Kolin Advanced and Synbiotic D-C both contain the probiotic Enterococcus faecium, so they overlap rather than stack when it comes to the probiotic itself.
Pro-Kolin Advanced is a short-term paste with extra binders (kaolin and montmorillonite) plus pectin, beta-glucans and psyllium husk for acute, stubborn upsets.
Pro-Kolin Advanced is backed by a published, placebo-controlled clinical trial in dogs showing a 32% reduction in the duration of acute diarrhoea.
Synbiotic D-C is a single daily capsule for both dogs and cats, designed for long-term, everyday gut support, recommended around antibiotic courses, stressful events like kennelling or travel, dietary changes, and gastrointestinal disease.
A common approach is to use Pro-Kolin Advanced during a flare-up, then move to daily Synbiotic D-C once things have settled, or use Synbiotic D-C as an ongoing baseline between flare-ups.
If diarrhoea lasts beyond 48 hours, or comes with blood, lethargy or vomiting, see your vet rather than relying on either product.

The Short Answer

Pro-Kolin Advanced is for sudden tummy upsets, while Synbiotic D-C is for long-term gut health maintenance afterwards in either a dog or a cat.

Use Pro-Kolin Advanced when your dog or cat has a stubborn, active bout of diarrhoea, choosing the formula matched to your pet.

Once the paste has done its job over a few days, you can hand it over to Synbiotic D-C as an ongoing daily capsule to support recovery after the upset or as year-round maintenance for a pet prone to tummy trouble.

There's rarely a need to give the full dose of both at the same time, since the probiotic strain is the same in each. The value in combining them comes from sequencing, not doubling up.

Pro-Kolin Advanced vs Synbiotic D-C at a Glance

	Pro-Kolin Advanced	Synbiotic D-C
Format	Probiotic paste, syringe	Capsule (whole or sprinkled on food)
For	Dogs and cats (separate formulas for each)	Dogs and cats (one product)
Core probiotic	Enterococcus faecium	Enterococcus faecium (DSM 10663/NCIMB 10415)
Prebiotic	Preplex (FOS + acacia)	Preplex (FOS + acacia)
Binders/soothers	Kaolin, montmorillonite, pectin, psyllium husk	None — capsule is probiotic/prebiotic only
Extra support	Beta-glucans (both); taurine (cat formula only)	—
Best used for	Acute, stubborn short-term upsets	Daily/ongoing gut maintenance, post-antibiotic recovery
Typical use length	A few days, until stools firm up	Long-term daily use
Dosing	By weight, from a graduated syringe	One capsule daily (weight-based for larger doses)

What Each One Does

Pro-Kolin Advanced settles an active upset fast, while Synbiotic D-C keeps the gut in good shape day to day.

Pro-Kolin Advanced

Pro-Kolin Advanced is a paste you give when your pet's tummy has suddenly gone off. It combines a probiotic (Enterococcus faecium) with prebiotic fibres that feed the good bacteria already in the gut.

Alongside those, it uses pectin and psyllium husk — natural plant fibres that soak up excess water and help firm things up — plus kaolin and montmorillonite, two binding clays that work together to settle loose stools. Beta-glucans give the immune system a hand while the gut recovers.

There are separate dog and cat formulas, each flavoured for the species. The cat version also includes taurine, an amino acid cats need for a healthy immune system.

It's also been properly tested. In a study of 148 dogs with sudden-onset diarrhoea, dogs given Pro-Kolin Advanced recovered noticeably faster than those on a placebo — around 32 hours sooner on average — and were less likely to need a follow-up trip to the vet. 92% of them happily took the paste.

You dose it from the syringe based on your pet's weight, and use it for a few days while the upset settles, not ongoing.

Synbiotic D-C

Synbiotic D-C is a daily capsule that contains the same probiotic strain as Pro-Kolin Advanced, in a concentrated form, along with Preplex — a prebiotic blend that helps those good bacteria settle in and multiply.

One formula suits both dogs and cats, and it's commonly used around antibiotic courses, stressful stretches like boarding or travel, diet changes, or a bout of scavenging. It's suitable from a young age, and you can give the capsule whole or twist it open and sprinkle it over food — which makes it easy to work into a daily routine.

Can You Give Them Together?

Both products contain the same core probiotic, so giving Pro-Kolin Advanced and a full daily dose of Synbiotic D-C at the same time won't do much more than either on its own. You'd mostly be paying twice for the same thing.

What makes Pro-Kolin Advanced different during a flare-up is the extra ingredients — the clays and plant fibres that soak up water and firm things up. Synbiotic D-C doesn't have those.

So rather than doubling up on the same day, it works better to use them at different stages:

During the flare-up: use Pro-Kolin Advanced (the dog or cat formula, matched to your pet) as directed until stools firm up.
After the flare-up, or as an ongoing baseline: switch to daily Synbiotic D-C to support the gut microbiome longer term.

If your dog or cat has a sensitive stomach that flares up now and then, "paste for the flare, capsule for the in-between" is a sensible way to use both without wasting product.

How to Combine Them in Practice

Think of it as a handover. Pro-Kolin Advanced gets the upset under control, then Synbiotic D-C takes over for ongoing support. The same approach works for dogs and cats.

A typical sequence looks like this:

Start Pro-Kolin Advanced as soon as you notice the upset — using the formula that matches your pet, and dosing by weight as per the label.
Keep going for a few days until stools are firm again. If there's no improvement within 48 hours, or things are getting worse, stop and speak to your vet rather than extending the course.
Switch to Synbiotic D-C once things have settled — one capsule daily, or as your vet advises. This is especially worthwhile after a course of antibiotics or a change of diet, both of which can throw the gut off balance.
Stay on Synbiotic D-C if your pet has a generally sensitive tummy, and keep Pro-Kolin Advanced on hand for the next flare-up.

That way you're never giving two probiotics at once, and each product is doing the job it was made for.

When Should I See The Vet?

Neither product is a substitute for veterinary care if the upset is severe or ongoing.

Both Pro-Kolin Advanced and Synbiotic D-C are over-the-counter products meant to support a healthy gut or a mild-to-moderate short-term upset — not to manage a serious or ongoing condition on their own, in either dogs or cats.

See your vet if diarrhoea lasts more than 48 hours, keeps recurring, or comes with blood, lethargy, vomiting, or a loss of appetite.

For a pet with a diagnosed condition like IBD or chronic enteropathy, either product can play a supporting role, but only alongside your vet's actual treatment plan.

Vet Picks: Shop the Range

You can also browse the full range of vet-recommended dog probiotics or cat probiotics if you're weighing up other options for ongoing gut support.

FAQs

Do Pro-Kolin Advanced and Synbiotic D-C contain the same probiotic?

Yes. Both contain Enterococcus faecium, so giving both at the same time mostly overlaps rather than adds extra probiotic benefit, in dogs or cats. The main difference is Pro-Kolin Advanced's added binders and soothers (kaolin, montmorillonite, pectin, psyllium) for acute upsets, versus Synbiotic D-C's design for simple daily maintenance.

Should I give both every day?

There's usually no need. A common pattern is Pro-Kolin Advanced during an active flare-up, then Synbiotic D-C daily as ongoing support once things have settled.

Can I switch straight from Pro-Kolin Advanced to Synbiotic D-C?

Yes — once your pet's stools have firmed up on Pro-Kolin Advanced, you can move directly to daily Synbiotic D-C for longer-term gut support. There's no need to run them concurrently first.

Is Synbiotic D-C safe for long-term daily use?

Yes, Synbiotic D-C is designed for daily, long-term use as a gut maintenance supplement in both dogs and cats, unlike Pro-Kolin Advanced, which is intended for short-term, defined courses during an upset.

Is Pro-Kolin Advanced the same product for dogs and cats?

No — Pro-Kolin Advanced comes as separate dog and cat formulas with different flavourings, and the cat version also includes taurine. Make sure you're using the formula matched to your pet. Synbiotic D-C, by contrast, is a single product suitable for both.

Getting Your Pet Back to Feeling Themselves Again

Used well, these two products cover different ends of the same job: Pro-Kolin Advanced brings an acute upset back under control, and Synbiotic D-C keeps things steady day to day, whether you have a dog, a cat, or both. If your pet's upset isn't settling within 48 hours, or comes with any of the warning signs above, that's the point to bring your vet in rather than reaching for more of either product.